Isoflavone attenuates vascular contraction through inhibition of RhoA/Rho-kinase signaling pathway
نویسندگان
چکیده
Department of Pharmacology (Y.M.S., I.B., I.K.K.), Cardiovascular Research Institute (I.K.K.), Kyungpook National University School of Medicine, Daegu, 700-422, Republic of Korea; Department of Biochemistry, College of Natural Sciences (Y-H.K.), Division of Plant Biosciences, College of Agriculture and Life Sciences (Y-S.J., I-J.L., D.H.S., Y.H.H.), Kyungpook National University, Daegu, 702-701, Republic of Korea JPET Fast Forward. Published on June 24, 2008 as DOI:10.1124/jpet.108.138529
منابع مشابه
Isoflavone attenuates vascular contraction through inhibition of the RhoA/Rho-kinase signaling pathway.
Isoflavones decrease blood pressure, improve lipid profiles, and restore vascular function. We hypothesized that isoflavone attenuates vascular contraction by inhibiting RhoA/Rho-kinase signaling pathway. Rat aortic rings were denuded of endothelium, mounted in organ baths, and contracted with 11,9 epoxymethano-prostaglandin F(2alpha) (U46619), a thromboxane A2 analog, or KCl 30 min after the p...
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